Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis

Abstract

This report examines the molecular mechanism by which high-fidelity DNA polymerases select nucleotides during the replication of an abasic site, a non-instructional DNA lesion. This was accomplished by synthesizing several unique 5-substituted indolyl 2'-deoxyribose triphosphates and defining their kinetic parameters for incorporation opposite an abasic… (More)
DOI: 10.1093/nar/gkq925

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@inproceedings{Motea2011QuantifyingTE, title={Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis}, author={Edward A. Motea and Irene Lee and Anthony J. Berdis}, booktitle={Nucleic acids research}, year={2011} }