Quantifying the effect of surface ligands on dendron-DNA interactions: insights into multivalency through a combined experimental and theoretical approach.

@article{Jones2010QuantifyingTE,
  title={Quantifying the effect of surface ligands on dendron-DNA interactions: insights into multivalency through a combined experimental and theoretical approach.},
  author={Steven P Jones and Giovanni M Pavan and Andrea Danani and Sabrina Pricl and David K Smith},
  journal={Chemistry},
  year={2010},
  volume={16 15},
  pages={4519-32}
}
We report the synthesis, DNA binding ability and preliminary gene delivery profiles of dendrons with different amine surface groups, 1,3-diaminopropane (DAP), N,N-di-(3-aminopropyl)-N-(methyl)amine (DAPMA) and spermine (SPM). By using a combination of ethidium bromide displacement, gel electrophoresis and transfection assays, it is shown that the dendrons with SPM groups are the most effective DNA binders, while the DAPMA-functionalised dendrons were the most effective systems for gene delivery… CONTINUE READING

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