Quantifying the degree of sharing of genetic and non-genetic causes of gene expression variability across four tissues

@inproceedings{Alfonso2016QuantifyingTD,
  title={Quantifying the degree of sharing of genetic and non-genetic causes of gene expression variability across four tissues},
  author={Alfonso and Buil and Ana and Vi{\~n}uela and Andrew and A.. and Richard Brown and Mathew and N. and Davies and Ismael Padioleau and Debora Bielser and Luciana Romano and Daniel A Glass and Paola Di Meglio and Kerrin S. Small and Tim D. Spector and Emmanouil T. Dermitzakis},
  year={2016}
}
Gene expression can provide biological mechanisms which underlie genetic associations with complex traits and diseases, but often the most relevant tissue for the trait is inaccessible and a proxy is the only alternative. Here, we investigate shared and tissue specific patterns of variability in expression in multiple tissues, to quantify the degree of sharing of causes (genetic or non-genetic) of variability in gene expression among tissues. Using gene expression in ~800 female twins from the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Dermitzakis , Alternative Splicing QTLs in European and African Populations

  • J. D. Storey
  • Am J Hum Genet
  • 2015

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

  • G.T.E. Consortium
  • Science,
  • 2015

Human genomics. The human transcriptome across tissues and individuals

  • M Melé
  • Science,
  • 2015

Prediction of the gene expression in normal lung tissue by the gene expression in blood

  • Halloran, J.W
  • BMC Med Genomics,
  • 2015

Similar Papers

Loading similar papers…