Quantifying the Waddington landscape and biological paths for development and differentiation

  title={Quantifying the Waddington landscape and biological paths for development and differentiation},
  author={Jin Wanga and Kun Zhanga and Li Xua and Erkang Wanga},
  • Jin Wanga, Kun Zhanga, +1 author Erkang Wanga
  • Published 2011
We developed a theoretical framework to prove the existence and quantify the Waddington landscape as well as chreode-biological paths for development and differentiation. The cells can have states with the higher probability ones giving the different cell types. Different cell types correspond to different basins of attractions of the probability landscape. We study how the cells develop from undifferentiated cells to differentiated cells from landscape perspectives. We quantified the… CONTINUE READING

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