Quantifying the Uncertainty in Model Parameters Using Gaussian Process-Based Markov Chain Monte Carlo: An Application to Cardiac Electrophysiological Models

  title={Quantifying the Uncertainty in Model Parameters Using Gaussian Process-Based Markov Chain Monte Carlo: An Application to Cardiac Electrophysiological Models},
  author={J. Dhamala and John L. Sapp and Milan Horacek and Linwei Wang},
Estimation of patient-specific model parameters is important for personalized modeling, although sparse and noisy clinical data can introduce significant uncertainty in the estimated parameter values. This importance source of uncertainty, if left unquantified, will lead to unknown variability in model outputs that hinder their reliable adoptions. Probabilistic estimation model parameters, however, remains an unresolved challenge because standard Markov Chain Monte Carlo sampling requires… 
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