Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme

  title={Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme},
  author={Martijn F. Schenk and Ivan G. Szendro and Joachim Krug and J. Arjan G. M. de Visser},
  booktitle={PLoS genetics},
For a quantitative understanding of the process of adaptation, we need to understand its "raw material," that is, the frequency and fitness effects of beneficial mutations. At present, most empirical evidence suggests an exponential distribution of fitness effects of beneficial mutations, as predicted for Gumbel-domain distributions by extreme value theory. Here, we study the distribution of mutation effects on cefotaxime (Ctx) resistance and fitness of 48 unique beneficial mutations in the… CONTINUE READING
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