Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme

@inproceedings{Schenk2012QuantifyingTA,
  title={Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme},
  author={Martijn F. Schenk and Ivan G. Szendro and Joachim Krug and J. Arjan G. M. de Visser},
  booktitle={PLoS genetics},
  year={2012}
}
For a quantitative understanding of the process of adaptation, we need to understand its "raw material," that is, the frequency and fitness effects of beneficial mutations. At present, most empirical evidence suggests an exponential distribution of fitness effects of beneficial mutations, as predicted for Gumbel-domain distributions by extreme value theory. Here, we study the distribution of mutation effects on cefotaxime (Ctx) resistance and fitness of 48 unique beneficial mutations in the… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Adaptive walks and distribution of beneficial fitness effects.

Evolution; international journal of organic evolution • 2014
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 66 references

Adaptive walks and extreme value theory.

Physical review letters • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…