Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients.

@article{Rasey1996QuantifyingRH,
  title={Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients.},
  author={Janet S. Rasey and W J Koh and Michelle L. Evans and Lanell M. Peterson and Thomas Kirby Lewellen and Michael M. Graham and Kenneth A. Krohn},
  journal={International journal of radiation oncology, biology, physics},
  year={1996},
  volume={36 2},
  pages={
          417-28
        }
}
PURPOSE To assess pretreatment hypoxia in a variety of tumors using positron emission tomography (PET) after injection of the hypoxia-binding radiopharmaceutical [18F]fluoromisonidazole ([18F]FMISO). METHODS AND MATERIALS Tumor fractional hypoxic volume (FHV) was determined in 21 nonsmall cell lung cancer patients, 7 head and neck cancer patients, 4 prostate cancer patients, and 5 patients with other malignancies by quantitative PET imaging after injection of [18F]FMISO (0.1 mCi/kg). The FHV… CONTINUE READING

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