Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.

  title={Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.},
  author={Robert L. Jilka and Robert S. Weinstein and A. Michael Parfitt and Stavros C Manolagas},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={22 10},
Since the initial demonstration of the phenomenon in murine and human bone sections approximately 10 yr ago, appreciation of the biologic significance of osteoblast apoptosis has contributed greatly not only to understanding the regulation of osteoblast number during physiologic bone remodeling, but also the pathogenesis of metabolic bone diseases and the pharmacology of some of the drugs used for their treatment. It is now appreciated that all major regulators of bone metabolism including bone… CONTINUE READING


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