Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.

@article{Scott2013QuantifyingNA,
  title={Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.},
  author={Gregory David Scott and Allison D Fryer and David B Jacoby},
  journal={American journal of respiratory cell and molecular biology},
  year={2013},
  volume={48 1},
  pages={10-6}
}
The quantitative histological analysis of airway innervation using tissue sections is challenging because of the sparse and patchy distribution of nerves. Here we demonstrate a method using a computational approach to measure airway nerve architecture that will allow for more complete nerve quantification and the measurement of structural peripheral neuroplasticity in lung development and disease. We demonstrate how our computer analysis outperforms manual scoring in quantifying three… CONTINUE READING