Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.

  title={Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.},
  author={T. S. Merritt and Caitlin A Kuczynski and Efe Sezgin and Chen-Tseh Zhu and Seiji Kumagai and Walter F. Eanes},
  volume={182 2},
In this report, we use synthetic, activity-variant alleles in Drosophila melanogaster to quantify interactions across the enzyme network that reduces nicotinamide adenine dinucleotide phosphate (NADP) to NADPH. We examine the effects of large-scale variation in isocitrate dehydrogenase (IDH) or glucose-6-phosphate dehydrogenase (G6PD) activity in a single genetic background and of smaller-scale variation in IDH, G6PD, and malic enzyme across 10 different genetic backgrounds. We find significant… CONTINUE READING
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