Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.

@article{Merritt2009QuantifyingIW,
  title={Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.},
  author={T. S. Merritt and Caitlin A Kuczynski and Efe Sezgin and Chen-Tseh Zhu and Seiji Kumagai and Walter F. Eanes},
  journal={Genetics},
  year={2009},
  volume={182 2},
  pages={565-74}
}
In this report, we use synthetic, activity-variant alleles in Drosophila melanogaster to quantify interactions across the enzyme network that reduces nicotinamide adenine dinucleotide phosphate (NADP) to NADPH. We examine the effects of large-scale variation in isocitrate dehydrogenase (IDH) or glucose-6-phosphate dehydrogenase (G6PD) activity in a single genetic background and of smaller-scale variation in IDH, G6PD, and malic enzyme across 10 different genetic backgrounds. We find significant… CONTINUE READING
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A role for ATP - citrate lyase , malic enzyme , and pyruvate / citrate cycling in glucose - induced insulin secretion

  • S. R. M adiraju, A. A umais, E. J oly, M. P rentki
  • J . Biol . Chem .
  • 2007

Control of metabolism : What do we measure ?

  • D. D uvernell
  • Trends Biochem . Sci .
  • 2005

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