Quantifying hypoxia-induced chemoreceptor sensitivity in the awake rodent.

@article{Morgan2014QuantifyingHC,
  title={Quantifying hypoxia-induced chemoreceptor sensitivity in the awake rodent.},
  author={Barbara J Morgan and Russell Adrian and Melissa L Bates and John M. Dopp and Jerome A. Dempsey},
  journal={Journal of applied physiology},
  year={2014},
  volume={117 7},
  pages={
          816-24
        }
}
We evaluated several methods for characterizing hypoxic chemosensitivity in the conscious rat. Adult Sprague-Dawley rats (n = 30) were exposed to normobaric hypoxia [inspired oxygen fraction (Fio2) 0.15, 0.12, and 0.09]. We measured ventilation (V̇e; barometric plethysmography), arterial oxygen saturation (SpO2; pulse oximeter), and oxygen consumption and carbon dioxide production (V̇o2 and V̇co2; analysis of expired air). Linear regression analysis was used to define stimulus-response… CONTINUE READING

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