Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think.

@article{McDermott2011QuantifyingAC,
  title={Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think.},
  author={Daniel Scott McDermott and Steven M Varga},
  journal={Journal of immunology},
  year={2011},
  volume={187 11},
  pages={
          5568-76
        }
}
The number of virus-specific CD8 T cells increases substantially during an acute infection. Up to 90% of CD8 T cells are virus specific following lymphocytic choriomeningitis virus (LCMV) infection. In contrast, studies identifying virus-specific CD4 T cell epitopes have indicated that CD4 T cells often recognize a broader array of Ags than CD8 T cells, consequently making it difficult to accurately quantify the total magnitude of pathogen-specific CD4 T cell responses. In this study, we show… CONTINUE READING

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