Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's disease.

@article{Bartzokis2004QuantifyingAM,
  title={Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's disease.},
  author={George Bartzokis and P. H. Lu and Jim Mintz},
  journal={Journal of Alzheimer's disease : JAD},
  year={2004},
  volume={6 6 Suppl},
  pages={S53-9}
}
Myelin plays an essential role in brain structure and function and the human brain is uniquely dependent on the elaboration of this late invention of evolution. Our brain has the most extensive and protracted process of myelination that extends to approximately age 50 in cortical regions that have the highest risk for developing Alzheimer's disease (AD) pathology. This myelin-centered model of the human brain asserts that unique vulnerabilities of myelin, especially late-developed myelin, and… CONTINUE READING
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