Quantifying Slow Evolutionary Dynamics in RNA Fitness Landscapes

  title={Quantifying Slow Evolutionary Dynamics in RNA Fitness Landscapes},
  author={Petr {\vS}ulc and Andreas Wagner and Olivier C. Martin},
  journal={Journal of bioinformatics and computational biology},
  volume={8 6},
We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a very slow approach to the optimum, following on average an inverse power of the evolutionary time. In addition, our study of the trajectories shows that the out-of-equilibrium effects due to the evolutionary process are very weak. In particular, the distribution of genotypes is close to that arising during equilibrium… 
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