Quantifying Selection Acting on a Complex Trait Using Allele Frequency Time Series Data

@inproceedings{Illingworth2012QuantifyingSA,
  title={Quantifying Selection Acting on a Complex Trait Using Allele Frequency Time Series Data},
  author={Christopher J. R. Illingworth and Leopold Parts and Stephan Schiffels and Gianni Liti and Ville Mustonen},
  booktitle={Molecular biology and evolution},
  year={2012}
}
When selection is acting on a large genetically diverse population, beneficial alleles increase in frequency. This fact can be used to map quantitative trait loci by sequencing the pooled DNA from the population at consecutive time points and observing allele frequency changes. Here, we present a population genetic method to analyze time series data of allele frequencies from such an experiment. Beginning with a range of proposed evolutionary scenarios, the method measures the consistency of… CONTINUE READING
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