Quantifying Not Only Bone Loss, but Also Soft Tissue Swelling, in a Murine Inflammatory Arthritis Model Using Micro-Computed Tomography

@inproceedings{Perilli2015QuantifyingNO,
  title={Quantifying Not Only Bone Loss, but Also Soft Tissue Swelling, in a Murine Inflammatory Arthritis Model Using Micro-Computed Tomography},
  author={Egon Perilli and Melissa D. Cantley and Victor Marino and Tania N. Crotti and Malcolm D. Smith and David Haynes and Anak A. S. S. K. Dharmapatni},
  booktitle={Scandinavian journal of immunology},
  year={2015}
}
In rodent models of inflammatory arthritis, bone erosion has been non-invasively assessed by micro-computed tomography (micro-CT). However, non-invasive assessments of paw swelling (oedema) are still based on clinical grading by visual evaluation, or measurements by callipers, not always reliable for the tiny mouse paws. The aim of this work was to demonstrate a novel straightforward 3D micro-CT analysis protocol capable of quantifying not only joint bone erosion, but also soft tissue swelling… CONTINUE READING

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