Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue

  title={Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue},
  author={Rakesh Gurrala and C Ethan Byrne and Loren M. Brown and Rafael Felix P. Tiongco and Margarite D. Matossian and Jonathan J. Savoie and Bridgette M. Collins-Burow and Matthew E. Burow and Elizabeth C Martin and Frank H. Lau},
  journal={Frontiers in Bioengineering and Biotechnology},
Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth and metastasis. Current methods of quantifying these processes are incomplete, require simple or artificial matrixes, rely on uncommon imaging techniques, preclude the use of biological and technical replicates, require destruction of the tissue, or… 
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