Quantifying B‐mode images of in vivo rat mammary tumors by the frequency dependence of backscatter.

@article{Topp2001QuantifyingBI,
  title={Quantifying B‐mode images of in vivo rat mammary tumors by the frequency dependence of backscatter.},
  author={Karen A. Topp and James F. Zachary and William D. O’Brien},
  journal={Journal of Ultrasound in Medicine},
  year={2001},
  volume={20}
}
To evaluate the frequency dependence of ultrasonic backscatter for its ability to differentiate between neoplastic and healthy tissue. 
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35 Citations
Highly Influential Citations
1
Background Citations
9
Methods Citations
7

35 Citations

Citation Type

Citation Type

Parametric Imaging of Rat Mammary Tumors In Vivo for the Purposes of Tissue Characterization
  • M. Oelze, J. Zachary, W. O’Brien
  • Medicine
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • 2002
TLDR
Parametric imaging that uses estimates of scatterer properties in tissues may lead to detection and characterization (diagnosis) of diseased tissues on conventional sonographic scanning systems.
Quantification of Ultrasonic Scattering Properties of In Vivo Tumor Cell Death in Mouse Models of Breast Cancer1
Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging
TLDR
The distinctions in the scattering properties are clearly seen in the QUS images of the tumors and indicate that QUS imaging can be useful in differentiating between different types of mammary tumors.
Quantitative ultrasound characterization of locally advanced breast cancer by estimation of its scatterer properties.
TLDR
Overall, the binary classification results (tumor versus normal tissue) were more promising than tumor grade assessment and combinations of advanced parameters can further improve the separation of tumors from normal tissue compared to the use of linear regression parameters.
Characterization of tissue microstructure using ultrasonic backscatter: theory and technique for optimization using a Gaussian form factor.
TLDR
Scattering properties estimated inside the tumors and in surrounding tissues are shown to be distinct and showed a 44.8% increase of average scatterer diameter inside the tumor as compared to tissues outside the tumor.
State of the Art Methods for Estimating Backscatter Coefficients
Ultrasound, which is routinely used for diagnostic imaging applications, is mainly qualitative. However, novel quantitative ultrasound techniques are being developed for diagnosing disease,…
Ultrasonic detection of anti cancer treatment success using tissue acoustic properties and parametric imaging
In cancer therapy the estimation of the tissue response is of importance for its therapeutic success. However, the efficacy cannot be assessed easily during the treatment. Today Biopsy and nuclear…
Defining optimal axial and lateral resolution for estimating scatterer properties from volumes using ultrasound backscatter.
TLDR
A series of simulations and measurements from physical phantoms indicated the optimal lateral and axial sizes of the ROI, where estimate accuracy and precision were better than 10% and 5%, respectively, occurred at 4 to 5 beamwidths laterally and 15 to 20 spatial pulse lengths axially.
Quantitative Ultrasound in Soft Tissues
TLDR
This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.
A Test Phantom for Estimating Changes in the Effective Frequency of an Ultrasonic Scanner
  • T. Wilson, J. Zagzebski, Yadong Li
  • Medicine, Physics
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • 2002
TLDR
A test phantom is investigated to independently measure an effective imaging frequency, including effects of depth‐dependent attenuation and frequency filtering during echo reception, based on variations of the frequency dependence of backscatter with scatterer size.
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References

SHOWING 1-10 OF 18 REFERENCES
Frequency dependence of ultrasound attenuation and backscatter in breast tissue.
Anisotropy of the ultrasonic backscatter of myocardial tissue: I. Theory and measurements in vitro.
This research addresses the variations in the ultrasonic backscatter from specimens consisting of a suspension of approximately aligned cylindrical scatterers in a fluid medium as a function of the…
Identifying acoustic scattering sources in normal renal parenchyma from the anisotropy in acoustic properties.
Anisotropy of the ultrasonic backscatter of myocardial tissue: II. Measurements in vivo.
TLDR
Even though angular dependence of the backscatter from tissues with directionally oriented structures is substantial, the anisotropy does not account for cardiac-cycle-dependent variation of backscattering, and the angular dependence should be incorporated in approaches to quantitative tissue characterization with ultrasound.
Comparison of theoretical scattering results and ultrasonic data from clinical liver examinations.
Progress in Two-Dimensional and Three-Dimensional Ultrasonic Tissue-Type Imaging of the Prostate Based on Spectrum Analysis and Nonlinear Classifiers.
TLDR
Color-encoded and gray-scale images derived from neural network assignment of suspicion for cancer at each pixel location showed remarkable detail and suggested potential clinical value for biopsy guidance using real-time two-dimensional images and staging, treatment planning, and monitoring using three- dimensional images.
Parametric (integrated backscatter and attenuation) images constructed using backscattered radio frequency signals (25-56 MHz) from human aortae in vitro.
Ultrasonic spectrum analysis for assays of different scatterer morphologies: theory and very-high frequency clinical results
Theoretical results are obtained to describe how clinically measured ultrasonic spectral parameters are related to effective physical properties of tissue scatterers. Scatterer morphologies include…
Anisotropy of ultrasonic propagation and scattering properties in fresh rat skeletal muscle in vitro.
TLDR
The largest anisotropy is seen in the backscatter coefficient, most notably in the semimembranosus where the magnitude at 90 degrees is over an order of magnitude greater than at 45 degrees, with the frequency dependence in both cases giving a power law between 1.5 and 2.0.
Ultrasonic measurement of glomerular diameters in normal adult humans.
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