Quantification of weal reactions with laser Doppler flowmetry. Comparative blood flow measurements of the oedematous centre and the perilesional flare of skin-prick histamine weals.


Skin-prick experiments with different concentrations of histamine (0.1 mg/ml, 1.0 mg/ml, 10.0 mg/ml) and isotonic NaCl solution for control were performed on the forearms of 10 healthy volunteers. Regular recordings of the cutaneous blood flow by laser Doppler flowmetry were performed in the centre of the weals and 5, 10, 15 and 20 mm from the centre… (More)