Quantification of underivatised amino acids on dry blood spot, plasma, and urine by HPLC-ESI-MS/MS.

@article{Giordano2012QuantificationOU,
  title={Quantification of underivatised amino acids on dry blood spot, plasma, and urine by HPLC-ESI-MS/MS.},
  author={Giuseppe Giordano and Iole Maria Di Gangi and Antonina Gucciardi and Mauro Naturale},
  journal={Methods in molecular biology},
  year={2012},
  volume={828},
  pages={219-42}
}
Enzyme deficiencies in amino acid (AA) metabolism affecting the levels of amino acids and their derivatives in physiological fluids may serve as diagnostically significant biomarkers for one or a group of metabolic disorders. Therefore, it is important to monitor a wide range of free amino acids simultaneously and to quantify them. This is time consuming if we use the classical methods and more than ever now that many laboratories have introduced Newborn Screening Programs for the… CONTINUE READING
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