Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.

@article{Aubert2015QuantificationOT,
  title={Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.},
  author={Daniel F. Aubert and Sherry S-J Hu and Miguel A Valvano},
  journal={Microbiology},
  year={2015},
  volume={161 11},
  pages={2161-73}
}
The Gram-negative bacterial type VI secretion system (T6SS) delivers toxins to kill or inhibit the growth of susceptible bacteria, while other secretion systems target eukaryotic cells. Deletion of atsR, a negative regulator of virulence factors in B. cenocepacia K56-2, increases T6SS activity. Macrophages infected with a K56-2 ΔatsR mutant display dramatic alterations in their actin cytoskeleton architecture that rely on the T6SS, which is responsible for the inactivation of multiple Rho… CONTINUE READING

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