Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2).

@article{Wang2002QuantificationOT,
  title={Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2).},
  author={Wengang Wang and Stefania Risso Bradley and George B Richerson},
  journal={The Journal of physiology},
  year={2002},
  volume={540 Pt 3},
  pages={951-70}
}
The medullary raphe nuclei contain putative central respiratory chemoreceptor neurones that are highly sensitive to acidosis. To define the primary stimulus for chemosensitivity in these neurones, the response to hypercapnic acidosis was quantified and compared with the response to independent changes in P(CO2) and extracellular pH (pH(o)). Neurones from the ventromedial medulla of neonatal rats (P0-P2) were dissociated and maintained in tissue culture for long enough to develop a mature… CONTINUE READING

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