Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.

@article{Jepson1997QuantificationOT,
  title={Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.},
  author={Annette P Jepson and Winston A S Banya and Fatoumatta Sisay-Joof and Musa Hassan-King and Carlo Nunes and Steve Bennett and Hilton C. Whittle},
  journal={Infection and immunity},
  year={1997},
  volume={65 3},
  pages={872-6}
}
Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gambian twins we report that regulation of the immune response to a variety of antigens from Plasmodium falciparum and Mycobacterium tuberculosis is controlled by factors which are… CONTINUE READING