Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry

@inproceedings{Blackbeard2007QuantificationOT,
  title={Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry},
  author={Julie Blackbeard and K. P. O’Dea and V C J Wallace and Andrew R. Segerdahl and Timothy Pheby and Masao Takata and M. J. Field and A S C Rice},
  booktitle={Journal of Neuroscience Methods},
  year={2007}
}
Microgliosis is implicated in the pathophysiology of several neurological disorders, including neuropathic pain. Consequently, perturbation of microgliosis is a mechanistic and drug development target in neuropathic pain, which highlights the requirement for specific, sensitive and reproducible methods of microgliosis measurement. In this study, we used the spinal microgliosis associated with L5 spinal nerve transection and minocycline-induced attenuation thereof to: (1) evaluate novel software… CONTINUE READING
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