Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS.

Abstract

The Annonaceous acetogenin annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family, whose consumption was linked to the occurrence of sporadic atypical Parkinsonism with dementia. A method for its quantification in Rat brain homogenates by UPLC-MS/MS in selected reaction monitoring (SRM) mode was developed… (More)
DOI: 10.1016/j.toxicon.2016.03.015

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