Quantification of the contractile response to injury: assessment of the work-length relationship in the intact heart.

@article{Morris1987QuantificationOT,
  title={Quantification of the contractile response to injury: assessment of the work-length relationship in the intact heart.},
  author={J. J. Morris and Gary L. Pellom and Charles E. Murphy and David R. Salter and Jacques P Goldstein and Andrew S. Wechsler},
  journal={Circulation},
  year={1987},
  volume={76 3},
  pages={
          717-27
        }
}
We used a sonomicrometric determination of ventricular dimension to examine the effect of ischemia and reperfusion on the work-length relationship in the intact heart to develop a useful and precise variable of ventricular contractile response to injury. Twenty anesthetized dogs were instrumented with epicardial ultrasonic dimension transducers to record right ventricular free wall chord length and left ventricular minor-axis length, micromanometers to record ventricular pressures, and an… 
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Methods Citations
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63 Citations

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Methods are needed to assess ventricular function after myocardial ischemia has been induced, particularly because of the increasing indications for open heart operations in patients who are seriously ill, and the nonlinear nature of the relationship between stroke work and end-diastolic volume has made it difficult to quantify ventricularfunction.
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It appears that increased uptake of free fatty acids, which increased threefold during epinephrine infusion, contributes to less efficient use of oxygen for mechanical work.
Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium.
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  • Medicine
    American journal of physiology. Heart and circulatory physiology
  • 1997
TLDR
In anesthetized pigs, asynchrony (Δ T) and nonuniformity (regional differences) in contractility ( Δ E) could describe the interaction between normal and stunned myocardium and both factors contribute, but the contribution shifts in favor of Δ E.
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References

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TLDR
It is concluded that linear end-systolic pressure-volume relationships can be derived in conscious dogs with intact sympathetic reflexes, and appears to reflect left ventricular contractile function and is indepednent of the level of afterload and preload.
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TLDR
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