Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.

@article{Arosio2014QuantificationOT,
  title={Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.},
  author={Paolo Arosio and Risto Cukalevski and Birgitta Frohm and Tuomas P. J. Knowles and Sara Linse},
  journal={Journal of the American Chemical Society},
  year={2014},
  volume={136 1},
  pages={219-25}
}
The aggregation of the amyloid beta peptide, Aβ42, implicated in Alzheimer's disease, is characterized by a lag phase followed by a rapid growth phase. Conventional methods to study this reaction are not sensitive to events taking place early in the lag phase promoting the assumption that only monomeric or oligomeric species are present at early stages and… CONTINUE READING