Quantification of the GH/IGF-axis components: lessons from human studies.

@article{Frystyk2012QuantificationOT,
  title={Quantification of the GH/IGF-axis components: lessons from human studies.},
  author={Jan Frystyk},
  journal={Domestic animal endocrinology},
  year={2012},
  volume={43 2},
  pages={186-97}
}
Originally, the circulating bioactivity of IGF-I was estimated by bioassays measuring the ability of serum to stimulate uptake of labeled sulfate or thymidine in cultures of costal cartilage or by the ability of serum to stimulate the uptake of glucose in fat tissue cultures. However, because of their laborious and unspecific nature, the original bioassays were quickly abandoned with the development of the first RIA for IGF-I in 1977. Consequently, for the past three decades the endogenous IGF… CONTINUE READING
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