Quantification of target analytes in various biofluids using a postcolumn infused-internal standard method combined with matrix normalization factors in liquid chromatography-electrospray ionization mass spectrometry.

@article{Liao2014QuantificationOT,
  title={Quantification of target analytes in various biofluids using a postcolumn infused-internal standard method combined with matrix normalization factors in liquid chromatography-electrospray ionization mass spectrometry.},
  author={Hsiao-wei Liao and I-lin Tsai and Guan-yuan Chen and Yen-shen Lu and Ching-hung Lin and Ching-Hua Kuo},
  journal={Journal of chromatography. A},
  year={2014},
  volume={1358},
  pages={85-92}
}
Liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) has become one of the most widely used methods in pharmaceutical laboratories. Although LC-ESI-MS provides high sensitivity and high specificity for quantifying target analytes in complicated biofluids, the associated severe matrix effects (MEs) generally result in large… CONTINUE READING