Quantification of sterol-specific response in human macrophages using automated imaged-based analysis

Abstract

The transformation of normal macrophage cells into lipid-laden foam cells is an important step in the progression of atherosclerosis. One major contributor to foam cell formation in vivo is the intracellular accumulation of cholesterol. Here, we report the effects of various combinations of low-density lipoprotein, sterols, lipids and other factors on human… (More)
DOI: 10.1186/s12944-017-0629-9

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10 Figures and Tables