Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

  title={Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.},
  author={Klaus Maier and Ute Hofmann and Alexander Bauer and Anja Niebel and Gabriele Vacun and Matthias Reuss and Klaus Mauch},
  journal={Metabolic engineering},
  volume={11 4-5},
The present work is the first to deal with the determination of cholesterol synthesis rates in primary rat hepatocytes using transient (13)C-flux analysis. The effects of statins on cholesterol biosynthesis and central carbon fluxes were quantified at a therapeutic concentration of 50 nM atorvastatin using carbon-labeled glutamine. The flux through the cholesterol pathway decreased from 0.27 to 0.08 mmol/l(cv)h in response to the administration of the hypolipidemic drug. Isotopic steady state… CONTINUE READING
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