Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding.

@article{Esterlis2010QuantificationOS,
  title={Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding.},
  author={I. Esterlis and Kelly P. Cosgrove and Jeffery C Batis and F. Bois and Stephanie M Stiklus and Evgenia Perkins and John P. Seibyl and Richard E. Carson and Julie K. Staley},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2010},
  volume={51 8},
  pages={1226-33}
}
UNLABELLED 5-(123)I-iodo-85380 ((123)I-5-IA) is used to quantitate high-affinity nicotinic acetylcholine receptors (beta(2)-nAChRs) on human SPECT scans. The primary outcome measure is V(T)/f(P), the ratio at equilibrium between total tissue concentration (free, nonspecifically bound, and specifically bound) and the free plasma concentration. Nondisplaceable uptake (free plus nonspecific) of (123)I-5-IA has not been measured in human subjects. Nicotine has high affinity for beta(2)*-nAChRs… CONTINUE READING