Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis.

@article{Li2013QuantificationOS,
  title={Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis.},
  author={Xin Li and Nathan M Young and Stephen Tropp and Diane Hu and Yanhua Xu and Benedikt Hallgr{\'i}msson and Ralph S Marcucio},
  journal={Human molecular genetics},
  year={2013},
  volume={22 25},
  pages={5160-72}
}
Fibroblast growth factor (FGF) signaling mutations are a frequent contributor to craniofacial malformations including midfacial anomalies and craniosynostosis. FGF signaling has been shown to control cellular mechanisms that contribute to facial morphogenesis and growth such as proliferation, survival, migration and differentiation. We hypothesized that FGF signaling not only controls the magnitude of growth during facial morphogenesis but also regulates the direction of growth via cell… CONTINUE READING
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