Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate.

@article{McCormick2008QuantificationOR,
  title={Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate.},
  author={A. Louise McCormick and R. H. Brown and Merit Ester Cudkowicz and Ammar Al-Chalabi and Jeremy A. Garson},
  journal={Neurology},
  year={2008},
  volume={70 4},
  pages={278-83}
}
BACKGROUND Retroviral involvement in amyotrophic lateral sclerosis (ALS) has been suspected for several years since the recognition that both murine and human retroviruses can cause ALS-like syndromes. Nonquantitative studies have demonstrated the retroviral enzyme reverse transcriptase (RT) in ALS patients' sera, but the amount and source of RT activity are unknown. We therefore developed a quantitative assay to study RT levels in ALS and examined the possibility that the recently discovered… CONTINUE READING