Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma.

@article{Napoli1985QuantificationOR,
  title={Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma.},
  author={Joseph L Napoli and B C Pramanik and Jacinta B. Williams and Marcia I. Dawson and Peter D. Hobbs},
  journal={Journal of lipid research},
  year={1985},
  volume={26 3},
  pages={
          387-92
        }
}
An assay based on negative ion chemical ionization mass spectrometry has been developed to quantify retinoic acid in plasma or serum. The lower limit of detection is 75 pg (240 fmol); normal values of retinoic acid can be determined on as little as 40 microliters of human plasma. The plasma concentrations of total retinoic acid in 12 healthy male volunteers taking no medication or vitamin supplementation ranged from 2.8 to 6.6 ng/ml; the mean was 4.9 ng/ml. The assay can be manipulated to… CONTINUE READING
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