• DOI:10.1021/ac100627e
Corpus ID: 29450125

Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling.

@article{Galuska2010QuantificationON,
  title={Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling.},
  author={S. Galuska and H. Geyer and B. Weinhold and M. Kontou and Ren{\'e} C R{\"o}hrich and U. Bernard and R. Gerardy-Schahn and W. Reutter and A. M{\"u}nster-K{\"u}hnel and R. Geyer},
  journal={Analytical chemistry},
  year={2010},
  volume={82 11},
  pages={
          4591-8
        }
}

S. Galuska, H. Geyer, +7 authors R. Geyer

Published 2010

Chemistry, Medicine

Analytical chemistry

Sialic acids usually represent the terminal monosaccharide of glycoconjugates and are directly involved in many biological processes. The cellular concentration of their nucleotide-activated form is one pacemaker for the highly variable sialylation of glycoconjugates. Hence, the determination of CMP-sialic acid levels is an important factor to understand the complex glycosylation machinery of cells and to standardize the production of glycotherapeutics. We have established a highly sensitive… CONTINUE READING

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