Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling.

@article{Galuska2010QuantificationON,
  title={Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling.},
  author={Sebastian P Galuska and Hildegard Geyer and Birgit Weinhold and Maria Kontou and Ren{\'e} C R{\"o}hrich and Ulrike Bernard and Rita Gerardy-Schahn and Werner Reutter and Anja K. M{\"u}nster-K{\"u}hnel and Robert P. Geyer},
  journal={Analytical chemistry},
  year={2010},
  volume={82 11},
  pages={
          4591-8
        }
}
Sialic acids usually represent the terminal monosaccharide of glycoconjugates and are directly involved in many biological processes. The cellular concentration of their nucleotide-activated form is one pacemaker for the highly variable sialylation of glycoconjugates. Hence, the determination of CMP-sialic acid levels is an important factor to understand the complex glycosylation machinery of cells and to standardize the production of glycotherapeutics. We have established a highly sensitive… CONTINUE READING
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