Quantification of myocardial muscarinic receptors with PET in humans.

  title={Quantification of myocardial muscarinic receptors with PET in humans.},
  author={Jacques Delforge and Dominique Le Guludec and Andr{\'e} Syrota and Bernard Bendriem and Christian Crouzel and Michel Slama and Pascal Merlet},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={34 6},
The potential for noninvasive quantification of myocardial muscarinic receptors using PET data, a mathematical model, multi-injection protocols and 11C-labeled methylquinuclidinyl benzilate (MQNB) as a radioligand was previously demonstrated in dogs. The present study examines the possibility of optimizing the experimental protocol to make this approach suitable for human studies. For six normal subjects, the protocol included three injections: a tracer injection, followed 30 min later by an… CONTINUE READING
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