Quantification of mycophenolate mofetil in human skin extracts using high-performance liquid chromatography-electrospray mass spectrometry.

@article{Pltzer2001QuantificationOM,
  title={Quantification of mycophenolate mofetil in human skin extracts using high-performance liquid chromatography-electrospray mass spectrometry.},
  author={Manuela Pl{\"a}tzer and Konstanze Jahn and Johannes Wohlrab and Reinhard H. H. Neubert},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={2001},
  volume={755 1-2},
  pages={355-9}
}
A sensitive and selective method for the quantification of mycophenolate mofetil and its active metabolite mycophenolic acid in different human skin layers after dermal administration is presented. The skin layers were separated after in vitro penetration experiments and a methanolic extraction was performed. Positive ion electrospray HPLC-MS in selected ion monitoring mode was used to quantify the substances after isocratic separation by a C18 analytical column. The minimum detectable… CONTINUE READING