Quantification of mucosal leucocyte endothelial cell interaction by in vivo fluorescence microscopy in experimental colitis in mice

@article{Farkas2001QuantificationOM,
  title={Quantification of mucosal leucocyte endothelial cell interaction by in vivo fluorescence microscopy in experimental colitis in mice},
  author={Stefan A. Farkas and Hans H. Herfarth and Matthias R{\"o}ssle and J Schroeder and Markus G M Steinbauer and Markus Otto Guba and Alexander W. Beham and Juergen Schölmerich and Karl-W. Jauch and Matthias Anthuber},
  journal={Clinical \& Experimental Immunology},
  year={2001},
  volume={126}
}
Leucocyte recruitment to sites of intestinal inflammation is a crucial, multi‐step process that leads ultimately to the accumulation of cells in the inflamed tissue. We established a new in vivo model system of experimental colitis to quantify leucocyte–endothelial cell interaction and leucocyte extravasation in the inflamed mucosa of the colon. Furthermore, we investigated the pathophysiological role of ICAM‐1 in the intestinal microcirculation in vivo. Using the model of dextran sodium… 
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