Quantification of linezolid in serum by LC-MS/MS using semi-automated sample preparation and isotope dilution internal standardization.


BACKGROUND Linezolid serum concentrations have been shown to be highly variable in critically ill patients with often sub-therapeutic drug levels regarding minimal inhibitory concentrations for relevant pathogens. Consequently, therapeutic drug monitoring of linezolid must be considered, requiring a reliable and convenient analytical method. We therefore… (More)
DOI: 10.1515/cclm-2013-0594


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