Quantification of intravascular and extravascular contributions to BOLD effects induced by alteration in oxygenation or intravascular contrast agents.

@article{Zhong1998QuantificationOI,
  title={Quantification of intravascular and extravascular contributions to BOLD effects induced by alteration in oxygenation or intravascular contrast agents.},
  author={Jianhui Zhong and Richard P. Kennan and Robert K. Fulbright and John C. Gore},
  journal={Magnetic resonance in medicine},
  year={1998},
  volume={40 4},
  pages={
          526-36
        }
}
A simple model is presented that allows quantitative separation of the contributions of signals from water in blood and extravascular parenchyma due to changes in blood oxygenation, induced either by brain activation or by alteration of inspired oxygen. The separation is based on the progressive attenuation of the signals in the vasculature of different levels when bipolar field gradient pulses are applied. Diffusion-weighted spin-echo echo-planar imaging sequences were used to measure signal… CONTINUE READING

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