Quantification of information transfer via cellular signal transduction pathways

@article{Kholodenko1997QuantificationOI,
  title={Quantification of information transfer via cellular signal transduction pathways},
  author={Boris N. Kholodenko and Jan B. Hoek and Hans V. Westerhoff and G. C. Brown},
  journal={FEBS Letters},
  year={1997},
  volume={414}
}
A conceptual framework is developed for the quantitative analysis of signal transfer through cellular signal transduction pathways and networks. This approach is referred to as signal transfer analysis and is based on formalisms that were first developed for the analysis of metabolic networks. Signal transduction is quantified as the sensitivity, known as the response coefficient of a target (e.g. an ion channel or transcription factor) to a signal (e.g. a hormone, growth factor or… 
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