Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson disease.

  title={Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson disease.},
  author={Kevin J. Black and Jonathan M. Koller and Meghan C. Campbell and Debra A. Gusnard and Stephen I. Bandak},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 48},
Adenosine A(2a) receptor antagonists reduce symptom severity in Parkinson disease (PD) and animal models. Rodent studies support the hypothesis that A(2a) antagonists produce this benefit by reducing the inhibitory output of the basal ganglia indirect pathway. One way to test this hypothesis in humans is to quantify regional pharmacodynamic responses with cerebral blood flow (CBF) imaging. That approach has also been proposed as a tool to accelerate pharmaceutical dose finding, but has not yet… CONTINUE READING
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