Quantification of in vivo replicative capacity of HIV-1 in different compartments of infected cells.

@article{Funk2001QuantificationOI,
  title={Quantification of in vivo replicative capacity of HIV-1 in different compartments of infected cells.},
  author={Georg A. Funk and Marek Fischer and Beda Joos and Milos Opravil and Huldrych F. G{\"u}nthard and Bruno Ledergerber and Sebastian Bonhoeffer},
  journal={Journal of acquired immune deficiency syndromes},
  year={2001},
  volume={26 5},
  pages={397-404}
}
Based on a mathematical model, we analyze the dynamics of CD4+ cells, actively, latently, persistently, and defectively infected cells and plasma virus after initiation of antiretroviral therapy in 14 HIV-1-infected asymptomatic patients. By simultaneous fitting of our model to clinical data of plasma HIV-1 RNA, peripheral blood mononuclear cell (PBMC)-gag RNA, proviral DNA, and CD4+ cell counts, we estimate kinetic parameters to determine the basic reproductive rate (R0) of the virus in… CONTINUE READING

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