Quantification of in vivo Photofrin uptake by human pituitary adenoma tissue.

@article{Igbaseimokumo2004QuantificationOI,
  title={Quantification of in vivo Photofrin uptake by human pituitary adenoma tissue.},
  author={Usiakimi Igbaseimokumo},
  journal={Journal of neurosurgery},
  year={2004},
  volume={101 2},
  pages={
          272-7
        }
}
OBJECT Photofrin is widely distributed in the body after intravenous injection. This study was designed to quantify the preferential uptake of Photofrin by pituitary adenoma tissue for intraoperative photodynamic therapy. METHODS Eight patients (seven men) with recurrent pituitary adenomas who had undergone previous surgery and radiation therapy were recruited for a Phase I/II feasibility study of the application of photodynamic therapy to pituitary tumors. Photofrin was administered… 
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7 Citations

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Citation Type

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TLDR
Some selectivity is found in Photofrin uptake between tumor and normal tissues of the peritoneal cavity, but absolute differences in drug uptake relative to toxicity-limiting normal tissues (intestine) are small.
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Pilot Study on Light Dosimetry Variables for Photodynamic Therapy of Barrett's Esophagus with High-Grade Dysplasia
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Esophageal thickness is the strongest predictor of treatment outcome in PDT, and “Photodynamic dose” for esophageaal PDT should incorporate the esophagal thickness.
Tumor vascular microenvironment determines responsiveness to photodynamic therapy.
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Findings show that photosensitizer localization to collagen increases vascular damage and improves treatment efficacy in tumors with greater collagen content, and the vascular basement membrane is identified to be a determinant of therapeutic outcome in PDT of tumors.
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TLDR
Most photosensitizer photochemical parameters discussed in this review are of the type II (singlet oxygen) photooxidation category, although type I photoensitizers that involve other reactive oxygen species (ROS) will be discussed as well.
Photodynamic Therapy: Fundamentals and Dosimetry
TLDR
Abbreviations: AK, Actinic Keratosis, ALA, aminolevulinic acid, HPD, hematoporphyrin derivative, ISC, Intersystem crossing, LED, light-emitting diode, MLu, motexafin lutetium, mTHPC, meso-tetrahydroyphenol chlorin, PDT, Photodynamic therapy, PIT, photoimunotherapy.
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