Quantification of histone acetyltransferase and histone deacetylase transcripts during early bovine embryo development.

@article{McGraw2003QuantificationOH,
  title={Quantification of histone acetyltransferase and histone deacetylase transcripts during early bovine embryo development.},
  author={Serge McGraw and Claude Robert and Lyne Massicotte and Marc-Andr{\'e} Sirard},
  journal={Biology of reproduction},
  year={2003},
  volume={68 2},
  pages={383-9}
}
Mammalian oocytes are very unique cells with an unlimited developmental potential. These totipotent cells are able to remove existing gene-expression patterns and to impose new ones. However, genome reprogramming is still a mystery. Posttranslational modifications by acetylation of the N-termini portion of histones composing the nucleosome are involved in genome reprogramming. These modifications alter the higher-order chromatin structure to render the DNA accessible to the regulatory and… CONTINUE READING

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