Quantification of histologic regression of rectal cancer after irradiation: a proposal for a modified staging system.

@article{Wheeler2002QuantificationOH,
  title={Quantification of histologic regression of rectal cancer after irradiation: a proposal for a modified staging system.},
  author={James M D Wheeler and Bryan F. Warren and N. J. M. C. Mortensen and N Ekanyaka and Hakan Kulaçoğlu and Adrian Jones and Bruce D. George and Michael G W Kettlewell},
  journal={Diseases of the colon and rectum},
  year={2002},
  volume={45 8},
  pages={1051-6}
}
PURPOSE Long-course preoperative radiotherapy has been recommended for rectal carcinoma when there is concern about the ability to perform a curative resection, for example, in larger tethered tumors or those sited anteriorly or near the anal sphincter. "Downstaging" of the tumor may occur, and this is of importance when estimating the prognosis and selecting postoperative therapy for patients. We studied the effects of preoperative chemoradiotherapy on the pathology of rectal cancer, and we… CONTINUE READING

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