Quantification of high-specificity cyclic diguanylate signaling.

  title={Quantification of high-specificity cyclic diguanylate signaling.},
  author={Jonathan P Massie and Evan L Reynolds and Benjamin J Koestler and J P Cong and Marco Agostoni and Christopher M. Waters},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 31},
Cyclic di-GMP (c-di-GMP) is a second messenger molecule that regulates the transition between sessile and motile lifestyles in bacteria. Bacteria often encode multiple diguanylate cyclase (DGC) and phosphodiesterase (PDE) enzymes that produce and degrade c-di-GMP, respectively. Because of multiple inputs into the c-di-GMP-signaling network, it is unclear whether this system functions via high or low specificity. High-specificity signaling is characterized by individual DGCs or PDEs that are… CONTINUE READING
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