Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply.

@article{Kerr2006QuantificationOH,
  title={Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply.},
  author={Jeffrey B. Kerr and R J Duckett and Michelle Myers and Kara L. Britt and Tajanka Mladenovska and John K. Findlay},
  journal={Reproduction},
  year={2006},
  volume={132 1},
  pages={
          95-109
        }
}
Proliferation and partial meiotic maturation of germ cells in fetal ovaries is believed to establish a finite, non-renewable pool of primordial follicles at birth. The supply of primordial follicles in postnatal life should be depleted during folliculogenesis, either undergoing atresia or surviving to ovulation. Recent studies of mouse ovaries propose that intra- and extraovarian germline stem cells replenish oocytes and form new primordial follicles. We quantified all healthy follicles in… Expand
Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries.
TLDR
These observations indicate that there are substantial differences in follicular renewal between adult human and rat ovaries and to study interspecies differences when compared to the ovaries of rat females. Expand
The dynamics of the primordial follicle reserve.
TLDR
The controversial concept of postnatal oogenesis is discussed, which posits a rare population of oogonial stem cells that contribute new oocytes to partially compensate for the age-related decline in the primordial follicle reserve. Expand
A New Model of Development of the Mammalian Ovary and Follicles
TLDR
A novel cell type is identified, termed GREL for Gonadal Ridge Epithelial-Like, which is believed to penetrate into the ovary and develop into granulosa cells when associating with oogonia to form follicles, in contrast to the prevailing theory. Expand
Proliferating Cell Nuclear Antigen (PCNA) Regulates Primordial Follicle Assembly by Promoting Apoptosis of Oocytes in Fetal and Neonatal Mouse Ovaries
TLDR
It is demonstrated that PCNA regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries by inhibiting the increase of PCNA expression by RNA interference and down-regulation of Ing1b, a PCNA-binding protein in the UV-induced apoptosis regulation. Expand
Gonadotropin treatment augments postnatal oogenesis and primordial follicle assembly in adult mouse ovaries?
TLDR
The results of the present study show that gonadotropin (PMSG) treatment to adult mouse leads to increased pluripotent stem cell activity in the ovaries, associated with increased meiosis, appearance of several cohorts of PF and their assembly in close proximity of OSE. Expand
Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cells.
TLDR
OSCs represent a unique type of totipotent adult stem cells, which could be utilized for autologous treatment of premature ovarian failure and also for autologistous stem cell therapy of neurodegenerative diseases without use of allogeneic embryonic stem cells or somatic cell nuclear transfer. Expand
The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion.
TLDR
It is concluded that neo-folliculogenesis does not occur following chemical or γ-irradiation mediated depletion of the primordial follicle reserve. Expand
Neo-oogenesis: Has its existence been proven?
TLDR
In this study, the isolation of rare putative stem cells with germ-line characteristics in the OSE of post-menopausal human ovaries devoid of oocytes was documented and successfully developed ovarian cells and possible follicles by using porcine intestinal submucosa to reconstruct an ovarian defect. Expand
Current knowledge in the renewal capability of germ cells in the adult ovary.
  • O. Oktem, K. Oktay
  • Biology, Medicine
  • Birth defects research. Part C, Embryo today : reviews
  • 2009
TLDR
This review will provide an update on the molecular aspects of the formation of primordial germ cells (PGC), the precursors of adult gametocytes, beginning from their specification to their migration to prospective gonads and formation of the ovary and follicular structures. Expand
How Is the Number of Primordial Follicles in the Ovarian Reserve Established?1
TLDR
The regulatory steps that determine the number of primordial follicles and thus thenumber of oocytes in the ovarian reserve at birth are outlined, using the mouse as the model, interspersed with human data where available. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 91 REFERENCES
Germline stem cells and follicular renewal in the postnatal mammalian ovary
TLDR
It is shown that juvenile and adult mouse ovaries possess mitotically active germ cells that, based on rates of oocyte degeneration (atresia) and clearance, are needed to continuously replenish the follicle pool. Expand
Origin of germ cells and formation of new primary follicles in adult human ovaries
TLDR
Differentiation of primitive granulosa and germ cells from the bipotent mesenchymal cell precursors of TA in adult human ovaries represents a most sophisticated adaptive mechanism created during the evolution of female reproduction. Expand
Formation of Ovarian Follicles During Fetal Development in Sheep1
TLDR
It is hypothesize that most (i.e., >95%) of the granulosal cells in newly formed primordial follicles originate from the ovarian surface epithelium, and that the sequential events leading to follicle formation take place entirely within ovigerous cords. Expand
Eggs forever?
TLDR
It is premature to replace the paradigm that adult mammalian neo-oogenesis/folliculogenesis does not take place and the observations underpinning their hypothesis are addressed. Expand
FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation.
TLDR
The persistence of FIGalpha in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development, and the observation that null females do not express Zp1, Zp2 or Zp3 indicates that FIGalpha plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida required for fertilization and early embryonic survival. Expand
Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood
TLDR
It is shown that adult mouse ovaries rapidly generate hundreds of oocytes, despite a small premeiotic germ cell pool, and bone marrow transplantation restores oocyte production in wild-type mice sterilized by chemotherapy, as well as in ataxia telangiectasia-mutated gene-deficient mice, which are otherwise incapable of making oocytes. Expand
Evidence of apoptosis in human primordial and primary follicles.
TLDR
Apoptosis could be the process responsible for atresia of quiescent follicles and hence depletion of the ovarian germ stockpile, and follicular cells expressing Bcl-2 may therefore be the viable cells that escape the apoptotic process. Expand
Proliferating cell nuclear antigen marks the initiation of follicular growth in the rat.
TLDR
Whether increased proliferating cell nuclear antigen (PCNA) correlates with initiation of follicle growth and might therefore be useful for studying early events in this process is determined. Expand
Establishment of oocyte population in the fetal ovary: primordial germ cell proliferation and oocyte programmed cell death.
Strict control of cell proliferation and cell loss is essential for the coordinated functions of different cell populations in complex multicellular organisms. Oogenesis is characterized by a firstExpand
Apoptosis in the human ovary.
TLDR
The role of apoptosis and its regulation of human ovarian function is discussed, which seems to be the mechanism that makes the female biological clock tick. Expand
...
1
2
3
4
5
...