Quantification of gastrointestinal sodium channelopathy.

@article{Poh2012QuantificationOG,
  title={Quantification of gastrointestinal sodium channelopathy.},
  author={Yong Cheng Poh and Arthur Beyder and Peter R Strege and Gianrico Farrugia and Martin L. Buist},
  journal={Journal of theoretical biology},
  year={2012},
  volume={293},
  pages={
          41-8
        }
}
Na(v)1.5 sodium channels, encoded by SCN5A, have been identified in human gastrointestinal interstitial cells of Cajal (ICC) and smooth muscle cells (SMC). A recent study found a novel, rare missense R76C mutation of the sodium channel interacting protein telethonin in a patient with primary intestinal pseudo-obstruction. The presence of a mutation in a patient with a motility disorder, however, does not automatically imply a cause-effect relationship between the two. Patch clamp experiments on… CONTINUE READING

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